01Global signal
A modest total-score association
Continuous ASO correlated with PANS-31 total score (Spearman ρ = 0.305, p = 0.031), with a broad 95% bootstrap interval from 0.014 to 0.568.
BRAIN Journal Interactive Companion
Streptococcal Seroreactivity and Symptom Patterns
Article companion for “Streptococcal Seroreactivity and Neuropsychiatric Symptom Patterns Relevant to PANS/PANDAS in Young Adults”.
ASO × PANS-31 association
Primary association
Continuous ASO showed a modest association with total symptom burden.
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Article-based scientific overview
The study examined 50 young adult psychiatric patients selected using a pragmatic history consistent with previous streptococcal exposure. Its clearest corrected associations linked continuous ASO titres with tic and cognitive/motor symptom domains.
02Threshold result
The 200 IU/mL split was not significant
The binary comparison produced a 2.85-point mean difference, but its confidence interval included zero and the Mann–Whitney result was p = 0.139.
03Robust domains
Tics and cognitive/motor symptoms
Tics (ρ = 0.496, q = 0.0025) and cognitive/motor symptoms (ρ = 0.421, q = 0.0117) remained significant after BH-FDR correction.
ResultReported estimateInterpretation used here
Total scoreSpearman ρ = 0.305; p = 0.0312.Modest unadjusted continuous association.
Ticsρ = 0.496; q = 0.0025.Strongest multiplicity-robust domain result.
Cognitive/motorρ = 0.421; q = 0.0117.Second multiplicity-robust domain result.
Adjusted ASOB = 0.83 after adjustment for age, sex and paediatric history; p = 0.3846.The crude association was sensitive to measured developmental context.
Experimental Pathway
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Stage 01
Cohort
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Figure 01
ASO and PANS-31 total score
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